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高辉

，天津理工大学化学化工学院硕导，教授

专家简介：

高辉，1973年12月，天津理工大学化学化工学院硕导，教授

研究方向
生物医用高分子合成及其性能研究,抗癌药物、蛋白质、肽类药物等的缓、控释体系,环境响应性智能给药系统
人才称号
教育部新世纪优秀人才支持计划人选；
学术兼职
European Journal of Pharmaceutics and Biopharmaceutics审稿人
讲授课程
药学专业英语，药事管理学，药用高分子材料
主要科研项目及代表性成果(包括鉴定项目、论文、专著、获奖、专利等)：

项目:

1. 国家自然科学基金项目：基于beta-环糊精的反相高分子胶束的构建及其在肽类药物传输中的应用（21374079），2014.01-2017.12，83万，主持；

2. 国家自然科学基金项目：含 beta-环糊精高分子的合成、反相胶束的构建及其在肽类药物控制释放中的应用（21244004），2013.01-2013.12，10万，主持；

3. 国家自然科学基金项目：含多氢键给体的高分子的合成及其作为基因载体的性能研究（21074092），2011.01-2013.12, 35万，主持；

4. 2012年入选天津市高校“中青年骨干创新人才培养计划”2012年12月—2015年11月，45万，主持

5. 天津市自然科学基金：侧链降解型聚阳离子基因载体的合成及其性能研究（10JCYBJC26800），2010.10 - 2013.09，10万，主持；

6. 973计划前期专项：新型生物降解高分子纳米材料的合成及其环境响应性能（2009CB626612），2009.04-11.08，55万元，与南开大学马建标教授合作项目；是天津理工大学方负责人（结题）；

7. 天津市高等学校科技发展基金计划项目：羧基聚甲基丙烯酸甘油酯的合成及对阿霉素的控制释放（20090505），2009.12-2012.12，3万元，主持（结题）。

8. 教育部新世纪优秀人才支持计划，2012.01-2014.12，50万，主持；

论文:

1. H Gao, H Takemoto, Q Chen, M Naito, H Uchida, X Liu, K Miyata,* K Kataoka,* Regulated protonation of polyaspartamide derivatives bearing repeated aminoethylene side chains for efficient intracellular siRNA delivery with minimal cytotoxicity，Chem. Commun. 2015, 51, 3158-3161 (IF=6.72).

2. Gu W-X, Li Q-L, Lu H, Fang L, Chen Q, Y-W Yang,* Hui Gao*, Construction of stable polymeric vesicles based on azobenzene and beta-cyclodextrin grafted poly(glycerol methacrylate)s for potential applications in colon-specific drug delivery, Chem. Commun. 2015, 51, 4715-4718 (IF=6.72).

3. W-X Gu, M Zhu, N Song, X Du, Y-W Yang, H. Gao, * Reverse Micelles Based on Biocompatible β-Cyclodextrin Conjugated Polyethylene Glycol Block Polylactide for Protein Delivery. J. Mater. Chem. B, 2015, 3, 316–322.

4. X Du, N. Song, Y-W-Yang, G Wu, J Ma, H Gao.* Reverse micelles based on β-cyclodextrin-incorporated amphiphilic polyurethane copolymers for protein delivery, 2014, Polym. Chem. 5300-5309（IF=5.37）.

5. W-X Gu, Y-W Yang, J Wen, H Lu, H Gao * Construction of Reverse Vesicles from Pseudo-Graft Poly(Glycerol Methacrylate)s via Cyclodextrin-Cholesterol Interaction. Polym. Chem. 2014, 5, 6344–6349. (IF=5.37）.

6. Q-L Li, L-ZWang, X-.Qiu, Y-L Sun, P-XWang, Y Liu, F Li, A-D Qi, H Gao,* Y-W Yang,* Stimuli-responsive biocompatible nanovalve based on β-cyclodextrin modified poly(glycidyl methacrylate), 2014, Polym. Chem. 2014, 5, 3389-3395 （IF=5.37）.

7. Q-L Li, W Gu, H. Gao, * Yang, Y.-W.* Self-Assembly and Applications of Poly(Glycidyl Methacrylate)s and Their Derivatives. Chem. Commun. 2014, 50, 13201–13215. (IF: 6.718 ) .

8. L Wang, Y.-W. Yang, M. Zhu, G Qiu, G Wu, H Gao.* β-Cyclodextrin-conjugated amino poly(glycerol methacrylate)s for efficient insulin delivery, 2014, RSC Adv., 2014,4, 6478-6485 (IF=3.70).

9. Q-L Li, Y Sun, Y -L Sun, J Wen, Y Zhou, Q Bing, L Isaacs, Y Jin, H Gao, * Y-W Yang,* Mesoporous Silica Nanoparticles Coated by Layer-by-Layer Self-Assembly Using Cucurbit[7]uril for in Vitro and in Vivo Anticancer Drug Release. Chem. Mater. 2014, 26, 6418–6431. (IF= 8.535).

10. D-E Liu, H Han, H Lu, G Wu, Y Wang, J Ma, Hui Gao*, Synthesis of amphiphilic polyaspartamide derivatives and construction of reverse mice, RSC Adv., 2014,4, 37130-37137 (IF=3.70).

11. H Han, D -E Liu, H Lu, W-X Gu, Hui Gao*, Construction of micelles based on biocompatible pseudo-graft polymers via b-cyclodextrin/cholesterol interaction for protein delivery, RSC Adv., 2014,4, 40882-40891 (IF=3.70).

12. Y Sun, Y.-L. Sun, L Wang, J. Ma, Y.-W. Yang,* H Gao.* Nanoassembles constructed from mesoporous silica nanoparticles and surface-coated multilayer polyelectrolytes for controlled drug delivery, 2014, Micropor. Mesopor. Mater. 185, 245-253(IF=3.37)..

13. Z Liang, M Zhu, Y.-W. Yang, Gao, H.* Antimicrobial activities of polymeric quaternary ammonium salts from poly(glycidyl methacrylate)s, 2014, Polym. Adv. Technol. 25, 117-122(IF=1.64)..

14. H Gao,* Z Liang, X Wu, C Li, Y-W Yang, G. Wu, J Ma, Quaternized poly(Glycerol Methacrylate)s for enhanced pDNA delivery, 2013, J. Controlled Release 172, e104-e105(IF=7.26)

15. C Li, Y-W Yang, Z-X Liang, G-L Wu, and H Gao* Post-modification poly(glycidyl methacrylate)s with alkyl amine and isothiocyanate for effective pDNA delivery, 2013, Polymer Chemistry, 4: 4366-4374 (IF=5.37)

16. Z Liang, Xi Wu, Y-W Yang, C Li, G Wu, and H Gao,* Quaternized amino poly(glycerol-methacrylate)s for enhanced pDNA deliver, 2013, Polymer Chemistry, 4: 3514-3523 (IF=5.3)

17. Y Sun, H Gao,* Y-W Yang, A Wang, G Wu, Y Wang, Yu Fan, J Ma, Layer-by-layer supramolecular assemblies based on linear and star-shaped poly(glycerol methacrylate)s for doxorubicin delivery. 2013, Journal of Biomedical Materials Research Part A, 101A: 2164-2173 (IF=2.6)

18. A Wang, H Gao,* Y Sun, Yu-long Sun, Y-W Yang, G Wu , Y Wang , Y Fan, J Ma, *Temperature- and pH-responsive nanoparticles of biocompatible polyurethanes for doxorubicin delivery, 2013, International Journal of Pharmaceutics, 441: 30-39 (IF=3.2)

19. W Gu, Y Ma, C Zhu, B Chen, J Ma, H Gao,* Synthesis of cross-linked carboxyl poly(glycerol methacrylate) and its application for the controlled release of doxorubicin, 2012, European Journal of Pharmaceutical Sciences 47 (3): 556-563(IF=3.2)

20. H Gao, M Elsabahy, EV Giger, DK Li, RE Prud’homme, and JC Leroux, Self assembling properties of aminated poly(glycerol methacrylate)s, Journal of controlled release 152: e142-143. (IF=5.7)；

21. Y N Ma, H Gao,* W X Gu, Y W Yang, Y N Wang, Y G Fan, G L Wu, and J B Ma, Carboxylated poly(glycerol methacrylate)s for doxorubicin delivery, Eur J Pharm Sci, 2012, 45: 65-72. （IDS Number: 892FL, IF=3.3）；

22. X Y Lu, H Gao, * C Li, Y W Yang, Y N Wang, Y G Fan, G L Wu, and J B Ma. Polyelectrolyte complex nanoparticles of amino poly(glycerol methacrylate)s and insulin, Int J Pharm, 2012, 423: 195-201. （IF=3.6）；

23. H Gao, Lu X Y, Y N Ma, Y W Yang, J F Li, G L Wu, Y N Wang, Y G Fan, and Ma J B*. Amino poly(glycerol methacrylate)s for oligonucleic acid delivery with enhanced transfection efficiency and low cytotoxicity, Soft Matter, 2011, 7: 9239-9247. （IDS Number: 822YE , IF=4.6）；

24. H Gao,* Y N Ma, X Y Lu, Y R Liang, B Q Chen, and J B Ma. PH-responsive nano-assemblies of amino poly(glycerol methacrylate), Eur Pol J, 2011, 47:1232-1239（IDS Number: 776GX, IF=2.9）；

25. H G Fu, H Gao,* G L Wu, Y N Wang, Y G Fan, and J B Ma. Preparation and tunable temperature-sensitivity of biodegradable polyurethane nanoassemblies from diisocyanate and poly(ethylene Glycol), Soft Matter, 2011, 7: 3546-3552（IDS Number: 738XZ, IF=4.6）；

26. X K Sun, H Gao,* G L Wu, Y N Wang, Y G Fan, and J B Ma. Biodegradable and temperature-responsive polyurethanes for adriamycin delivery, Int J Pharm, 2011,412:52-58（IDS Number: 793EH, IF=3.0）；

27. H. Gao, M. Elsabahy, E.V. Giger, D.K. Li, R.E. Prud’homme, J.C. Leroux, Aminated linear and star-shape poly(glycerol methacrylate)s: synthesis and self-assembling properties, Biomacromolecules, 2010, 11: 889-895.（IDS Number: 581WW, IF=5.8）；

28. J. Leblond, H. Gao, A. Petitjean, Leroux, J.C. Leroux, pH-Responsive molecular tweezers, J Am Chem Soc, 2010, 132：8544-8545. （IDS Number:, IF=8.6）；

29. H. Gao, M.-C. Jones, J. Chen, Y.R. Liang, R. E. Prud’homme, J.-C. Leroux, Hydrophilic nanoreservoirs embedded into polymeric nanoparticles - An approach to compatibilize polar molecules with hydrophobic matrices. Chem Mater, 2008 20: 4191–4193. （IDS Number: 321BM, IF=8.5）；

30. H. Gao, M.-C. Jones, J. Chen, R. E. Prud’homme, J.-C. Leroux, Core cross-linked reverse polymeric micelles. Chem Mater, 2008 20: 3063–3067. （IDS Number: 297NM, IF=8.5）；

31. M.-C. Jones, H. Gao, J.-C. Leroux, Reverse polymeric micelles for pharmaceutical applications. J. Controlled release, 2008 132:208-215. （IDS Number: 386SL, IF=7.3）；

32. H. Gao, Y.-N. Wang, Y.-G. Fan, J.-B. Ma. Ethylenediamino bridged bis(β-cyclodextrin)/ poly(DL-lactic-co-glycolic acid) nanoparticles prepared by modified double emulsion method: effect of polyvinyl alcohol on nanoparticle properties. J Appl Polym Sci, 2008 107: 571–576. （IDS Number: 229RP, IF=1.2）；

33. H. Gao, M.-C. Jones, P. Tewari, M. Ranger, J.-C. Leroux, Star-Shaped alkylated poly (glycerol methacrylate) reverse micelles: synthesis and evaluation of their solubilizing properties in dichloromethane. J Polym Sci Part A: Polym Chem, 2007 45:2425-2435. （IDS Number: 173SZ, IF=4.0）；

34. H. Gao, Y.-N. Wang, Y.-G. Fan, J.-B. Ma. Conjugates of poly(DL-lactide-co-glycolide) on amino cyclodextrins and their nanoparticles as protein delivery system. J Biomed Mater Res Pt A, 2007 80A:111-122. （IDS Number: 114PN, IF=2.8）；

35. H. Gao, Y.-N. Wang, Y.-G. Fan, J.-B. Ma. Conjugates of poly(DL-lactic acid) with ethylenediamino or diethylenetriamino bridged bis(beta-cyclodextrin)s and their nanoparticles as protein delivery systems. J control release, 2006 112:301-311. （IDS Number: 057NA, IF=7.3）；

36. H. Gao, Y.-N. Wang, Y.-G. Fan, J.-B. Ma. Interactions of some modified mono- and bis-beta-cyclodextrins with bovine serum albumin. Bioorgan & Med Chem, 2006 14:131-137. （IDS Number: 989YB, IF=2.8）；

37. H. Gao, Y.-N. Wang, Y.-G. Fan, J.-B. Ma. Synthesis of a biodegradable tadpole-shaped polymer via the coupling reaction of polylactide onto mono(6-(2-aminoethyl) amino-6-deoxy)- β -cyclodextrin and its properties as the new carrier of protein delivery system. J control release, 2005 107:158-173. （IDS Number: 970YW, IF=7.3）

专著:

1. 功能高分子材料，马建标主编，之第九章医用高分子材料，第二版：化学工业出版社,2010年.

专利：

1．高辉孙现科马建标。具有pH响应性的生物降解聚氨酯材料的制备方法，ZL201010511225.5

2．高辉顾文星马亚男陆学友马建标。一种具有PH响应性聚甲基丙烯酸甘油酯的制备方法，ZL201110282730.1

3．高辉；朱明冉。一种基于油相的两亲性高分子反相微乳的制备方法，201310454392.4

4．高辉；顾文星；王立志；郭盼。一种准嵌段共聚物反相高分子胶束的制备方法，201310420819.9

获奖:

1．马建标、王亦农、王小红、高辉、范云鸽，天然生物高分子的修饰及其生物医学性能（2010ZR-3-006）天津市自然科学三等奖（2010年）；

指导学生获得

1）第二届“天津市大学生创新、创业奖学金”顾文星获得“创新奖学金”优秀奖。

2）第十二届“挑战杯”全国大学生课外学术科技作品竞赛三等奖，天津市大学生课外学术科技作品竞赛特等奖：高分子的pH响应性能及其对抗癌药物的控制释放。人员：顾文星，朱楚宇、许祥、宋婧怡、王新雷

3）第八届中国青少年科技创新奖顾文星